EVALHEP

EValuation of Hepatic Lesion Removal by ElectroPoration

Underway

01/11/2022

30/11/2023

Main objectives

Irreversible electroporation is a curative treatment for cancerous lesions of the liver, performed when tumors are too deep and poorly located to be resected or destroyed by other means.

The EVALHEP project aims to develop criteria for evaluating the effectiveness of the treatment based on imaging, mathematical models and numerical simulations to assist the radiologist performing these complex procedures.

#Cancer | #HepatocellularCarcinoma | #IrreversibleElectroporation | #LiverCancer

Challenge

Although it has shown promising efficacy, irreversible electroporation (IRE) remains underutilized because it is considered a complex procedure subject to many variability factors. There is no real-time evaluation of the efficacy of the procedure and inaccuracies in needle positioning or treatment parameters will generate changes in the distribution of the electric field that may affect treatment efficacy. Moreover, it remains difficult to evaluate the effectiveness of the treatment on post-therapeutic images whose interpretation is subject to controversy.

Methodology/Technology used

Mathematical modeling; Numerical simulations of the electric field from 3D imagery; Estimation of motion and non-rigid inter-modality registration; Biomarkers in imaging (radiomics)

Publications

Contacts

Clair Poignard (Equipe MONC – Inria Bordeaux) () & Olivier Sutter (Unité de Radiologie Interventionnelle, hôpital Avicenne, Hôpitaux Universitaires Paris-Seine-Saint-Denis) ()

Members

AP-HP, Inria

Useful links

https://www.bernoulli-lab.fr/project/nepa-2/